Analysis of non-ignorable missing and left-censored longitudinal data using a weighted random effects tobit model.

نویسندگان

  • Abdus Sattar
  • Lisa A Weissfeld
  • Geert Molenberghs
چکیده

In a longitudinal study with response data collected during a hospital stay, observations may be missing because of the subject's discharge from the hospital prior to completion of the study or the death of the subject, resulting in non-ignorable missing data. In addition to non-ignorable missingness, there is left-censoring in the response measurements because of the inherent limit of detection. For analyzing non-ignorable missing and left-censored longitudinal data, we have proposed to extend the theory of random effects tobit regression model to weighted random effects tobit regression model. The weights are computed on the basis of inverse probability weighted augmented methodology. An extensive simulation study was performed to compare the performance of the proposed model with a number of competitive models. The simulation study shows that the estimates are consistent and that the root mean square errors of the estimates are minimal for the use of augmented inverse probability weights in the random effects tobit model. The proposed method is also applied to the non-ignorable missing and left-censored interleukin-6 biomarker data obtained from the Genetic and Inflammatory Markers of Sepsis study.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Marginal Analysis of A Population-Based Genetic Association Study of Quantitative Traits with Incomplete Longitudinal Data

A common study to investigate gene-environment interaction is designed to be longitudinal and population-based. Data arising from longitudinal association studies often contain missing responses. Naive analysis without taking missingness into account may produce invalid inference, especially when the missing data mechanism depends on the response process. To address this issue in the ana...

متن کامل

Prediction of Random Effects in Linear Mixed Models under Stochastic Censoring

Mixed model methodology is a tool of choice for analyzing correlated data in a large domain of disciplines and areas of application. Censored data are not rare in practice and they may cause serious defects in the estimation of parameters when not properly accounted for in the statistical analysis. A frequent phenomenon, which generates censored data, lies in the existence of limits of detectio...

متن کامل

A transition model for quality-of-life data with non-ignorable non-monotone missing data.

In this paper, we consider a full likelihood method to analyze continuous longitudinal responses with non-ignorable non-monotone missing data. We consider a transition probability model for the missingness mechanism. A first-order Markov dependence structure is assumed for both the missingness mechanism and observed data. This process fits the natural data structure in the longitudinal framewor...

متن کامل

A Non-Random Dropout Model for Analyzing Longitudinal Skew-Normal Response

In this paper, multivariate skew-normal distribution is em- ployed for analyzing an outcome based dropout model for repeated mea- surements with non-random dropout in skew regression data sets. A probit regression is considered as the conditional probability of an ob- servation to be missing given outcomes. A simulation study of using the proposed methodology and comparing it with a semi-parame...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Statistics in medicine

دوره 30 27  شماره 

صفحات  -

تاریخ انتشار 2011